Me3Sn-SDM-8 (SynVesT-1 trimethylstannyl precursor)

Precursor for PET tracer [¹⁸F]SDM-8 ([¹⁸F]-SynVesT-1)

Product number: PL-074-P1

Chemical name: (R)-4-(3-Fluoro-5-(trimethylstannyl)phenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidine-2-one

CAS No: 2289636-79-7

M. Weight: 447.13

M. Formula: C20H25FN2OSn

Purity: >98%

Certificate: CoA, ¹H NMR, ¹³C NMR, HPLC

Application: Neuroscience; Synaptic vesicle glycoprotein 2A (SV2A)

Remarks: Notice to the customers in the US: the 18F labelled derivative of this compound and its use for imaging of synaptic vesicle glycoprotein 2A (SV2A) are covered with an active patent (US11518754B2). Before ordering the precursor please make sure there are no legal restrictions for you to use it. For customers in Europe: according to our knowledge the European patent application (publication number EP3582771) for the same subject is currently pending.

Literature:
Neuroimage. 2023 Aug 15:277:120230
J Cereb Blood Flow Metab. 2022 Oct;42(10):1867-1878
J Labelled Comp Radiopharm. 2022 Oct;65(12):315-322
Mol Imaging. 2023 Sep 8;2023:8826977 (SDM-4 and SDM-8)